Suppression of saccadic intrusions in hereditary ataxia by memantine.
نویسندگان
چکیده
2008;70;810-812 Neurology A. Serra, K. Liao, S. Martinez-Conde, L. M. Optican and R. J. Leigh MEMANTINE SUPPRESSION OF SACCADIC INTRUSIONS IN HEREDITARY ATAXIA BY This information is current as of March 3, 2008 http://www.neurology.org/cgi/content/full/70/10/810 located on the World Wide Web at: The online version of this article, along with updated information and services, is All rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X. since 1951, it is now a weekly with 48 issues per year. Copyright © 2008 by AAN Enterprises, Inc. ® is the official journal of the American Academy of Neurology. Published continuously Neurology
منابع مشابه
Ocular-Motor Profile and Effects of Memantine in a Familial Form of Adult Cerebellar Ataxia with Slow Saccades and Square Wave Saccadic Intrusions
Fixation instability due to saccadic intrusions is a feature of autosomal recessive spinocerebellar ataxias, and includes square wave intrusions (SWI) and macrosaccadic oscillations (MSO). A recent report suggested that the non-competitive antagonist of NMDA receptors, memantine, could decrease MSO and improve fixation in patients with spinocerebellar ataxia with saccadic intrusions (SCASI). We...
متن کاملSaccades during Attempted Fixation in Parkinsonian Disorders and Recessive Ataxia: From Microsaccades to Square-Wave Jerks
During attempted visual fixation, saccades of a range of sizes occur. These "fixational saccades" include microsaccades, which are not apparent in regular clinical tests, and "saccadic intrusions", predominantly horizontal saccades that interrupt accurate fixation. Square-wave jerks (SWJs), the most common type of saccadic intrusion, consist of an initial saccade away from the target followed, ...
متن کاملA form of inherited cerebellar ataxia with saccadic intrusions, increased saccadic speed, sensory neuropathy, and myoclonus.
Over the past five years, rapid progress has been made in genetically identifying different forms of spinocerebellar atrophy (SCA), for which several characteristic disorders of eye movements have been reported.1,2 Nonetheless, the genetic disorder in some families has not yet been discovered, and this report concerns one such kinship. We studied a family of Slovenian descent in which 5 of 14 s...
متن کاملHereditary Ataxia with a Novel Mutation in the Senataxin Gene: A Case Report
Hereditary ataxias (HA) are a group of inherited neurological disorders caused by changes in genes. At least 115 different mutations in the senataxin (SETX) gene causing ataxia have been identified. There are no reports of any SETX gene mutation among the Iranian population. Here we report on two cases with homozygous and heterozygous mutations in which one patient was affected by HA with oculo...
متن کاملCharacteristic Eye Movements in Ataxia-Telangiectasia-Like Disorder: An Explanatory Hypothesis
Objective To investigate cerebellar dysfunctions and quantitatively characterize specific oculomotor changes in ataxia-telangiectasia-like disorder (ATLD), a rare autosomal recessive disease caused by mutations in the MRE11 gene. Additionally, to further elucidate the pathophysiology of cerebellar damage in the ataxia-telangiectasia (AT) spectrum disorders. Methods Saccade dynamics, metrics, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neurology
دوره 70 10 شماره
صفحات -
تاریخ انتشار 2008